stratum corneum chymotryptic enzyme EC#: 3.4.21.117; ChemWhat Code: 1380666
| Product Name | stratum corneum chymotryptic enzyme |
| Example Structure |  |
| Synonyms | hK7, HSCCE, human stratum corneum chymotryptic enzyme, K7, kallikrein 7, kallikrein-7, kallikrein-related peptidase, kallikrein-related peptidase 7, KLK7, More, S01.300, SCCE, stratum corneum chymotryptic enzyme, tissue kallikrein, tissue kallikrein 7 |
| EC Number | 3.4.21.117 |
| CAS Registry Number | |
| Comments | This enzyme has wide substrate specificity, being able to degrade heat-denatured bovine casein and the ¦Á-chain of native human fibrinogen. It cleaves the B chain of bovine insulin at Leu6©àCya7, Tyr16©àLeu17, Phe25©àTyr26?and Tyr26©àThr27?[1]. It is thought to play a role in the desquamation (skin-shedding) of the outer layer of skin, the stratum corneum, by degrading intercellular cohesive structures [1,2]. Belongs in peptidase family?S1A. |
| Cofactor | |
| History | |
| Reactions | Cleavage of proteins with aromatic side chains in the P1 position. |
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