taxadiene synthase EC#: 4.2.3.17; ChemWhat Code: 1382566
| Product Name | taxadiene synthase |
| Example Structure |  |
| Synonyms | geranylgeranyl pyrophosphate cyclase, taxa-4(5),11(12)-diene synthase, taxadiene synthase, taxadiene synthase 5, TXS |
| EC Number | 4.2.3.17 |
| CAS Registry Number | 169277-52-5 |
| Comments | This is the committed step in the biosynthesis of the diterpenoid antineoplastic drug Taxol (paclitaxel). The cyclization involves a 1,5-hydride shift. |
| Cofactor | |
| History | |
| Reactions | Geranylgeranyl diphosphate = taxa-4,11-diene + diphosphate. |
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