| Product Name |
tetracenomycin F2 synthase |
| Example Structure |
 |
| Synonyms |
TCM F2, TCM PKS, TcmK protein, TcmN polyketide cyclase, type II polyketide synthase |
| EC Number |
2.3.1.235 |
| CAS Registry Number |
|
| Comments |
A multi-domain polyketide synthase involved in the synthesis of tetracenomycin in the bacterium Streptomyces glaucescens. It involves a ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN). A malonyl-CoA molecule is initially bound to the acyl carrier protein and decarboxylated to form an acetyl starter unit. Additional two-carbon units are added from nine more malonyl-CoA molecules. |
| Cofactor |
|
| History |
|
| Reactions |
10 malonyl-CoA = tetracenomycin F2 + 10 CoA + 10 CO(2) + 2 H(2)O. |
