tetracycline 11a-monooxygenase EC#: 1.14.13.231; ChemWhat Code: 1375476

Product Name tetracycline 11a-monooxygenase
Example Structure Example Structure of tetracycline 11a-monooxygenase EC#: 1.14.13.231
Synonyms BN1088_100004, tetracycline resistance protein from transposon Tn4351/Tn4400, tetracylcine resistance protein TetX, TetX, TetX family tetracycline inactivation enzyme, TetX2
EC Number 1.14.13.231
CAS Registry Number
Comments A flavoprotein (FAD). This bacterial enzyme confers resistance to all clinically relevant tetracyclines when expressed under aerobic conditions. The hydroxylated products are very unstable and lead to intramolecular cyclization and non-enzymic breakdown to undefined products.
Cofactor FAD
History
Reactions Tetracycline + Nadph + O(2) = 11a-hydroxytetracycline + NADP(+) + H(2)O.

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