tetracycline 7-halogenase EC#: 1.14.19.49; ChemWhat Code: 1375814
| Product Name | tetracycline 7-halogenase |
| Example Structure |  |
| Synonyms | ctcP, Cts4 |
| EC Number | 1.14.19.49 |
| CAS Registry Number | |
| Comments | The enzyme, characterized from the bacterium Streptomyces aureofaciens, is a member of the flavin-dependent halogenase family. The enzyme forms a lysine chloramine intermediate on an internal lysine residue before transferring the chlorine to the substrate. It is stereo-selective for the 4S (natural) isomer of tetracycline. FADH2 is provided by a dedicated EC 1.5.1.36, flavin reductase (NADH). |
| Cofactor | |
| History | |
| Reactions | Tetracycline + FADH(2) + chloride + O(2) + H(+) = 7-chlorotetracycline + Fad + 2 H(2)O. |
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