thebaine 6-O-demethylase EC#: 1.14.11.31; ChemWhat Code: 1375116
| Product Name | thebaine 6-O-demethylase |
| Example Structure |  |
| Synonyms | T6ODM |
| EC Number | 1.14.11.31 |
| CAS Registry Number | |
| Comments | Requires Fe2+. Catalyses a step in morphine biosynthesis. The product neopinione spontaneously rearranges to the more stable codeinone. The enzyme also catalyses the 6-O-demethylation of oripavine to morphinone, with lower efficiency. |
| Cofactor | Fe2+ |
| History | |
| Reactions | Thebaine + 2-oxoglutarate + O(2) = neopinone + formaldehyde + succinate + CO(2). |
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