thymine dioxygenase EC#: 1.14.11.6; ChemWhat Code: 1375077

Product Name thymine dioxygenase
Example Structure Example Structure of thymine dioxygenase EC#: 1.14.11.6
Synonyms 5-hydroxy-methyluracil dioxygenase, 5-hydroxy-methyluracil oxygenase, Fe2+/2-oxoglutarate dependent hydroxylase, J binding protein 1, J binding protein 2, J-binding protein 1, J-binding protein 2, JBP1, JBP2, More, T7H, thymidine hydroxylase, thymine 7-hydroxylase, thymine dioxygenase, thymine hydroxylase, thymine-7-hydroxylase
EC Number 1.14.11.6
CAS Registry Number 37256-67-0
Comments Requires Fe2+ and ascorbate. Also acts on 5-hydroxymethyluracil to oxidize its -CH2OH group first to -CHO and then to -COOH.
Cofactor Fe2+;L-ascorbate
History
Reactions Thymine + 2-oxoglutarate + O(2) = 5-hydroxymethyluracil + succinate + CO(2).

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