thymine-DNA glycosylase EC#: 3.2.2.29; ChemWhat Code: 1380185
| Product Name | thymine-DNA glycosylase |
| Example Structure |  |
| Synonyms | G/T glycosylase, G:T mismatch-specific thymine DNA-glycosylase, hsTDG, hTDG, mismatch-specific thymine-DNA glycosylase, mismatch-specific thymine-DNA N-glycosylase, More, Pa-MIG, T/U mismatch DNA glycosylase, T:G mismatch-specific thymidine-DNA glycosylase, TDG, Thd1p, thymine DNA glycosylase, thymine DNA-glycosylase, thymine-DNA glycosylase, uracil/thymine DNA glycosylase |
| EC Number | 3.2.2.29 |
| CAS Registry Number | |
| Comments | Thymine-DNA glycosylase is part of the DNA-repair machinery. Thymine removal is fastest when it is from a G/T mismatch with a 5′-flanking C/G pair. The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T [3]. |
| Cofactor | |
| History | |
| Reactions | Hydrolyzes mismatched double-stranded Dna and polynucleotides, releasing free thymine. |
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