thyroxine 5′-deiodinase EC#: 1.21.99.4; ChemWhat Code: 1376101
| Product Name | thyroxine 5′-deiodinase |
| Example Structure |  |
| Synonyms | 5DI , 5DII , 5DIII , D1 5′-deiodinase, D2 5′-deiodinase, deiodinase, diiodothyronine 5′-deiodinase, Dio, DIO1, DIO2, DIOI , DIOII , DIOIII , EC 3.8.1.4, ID-1, ID-2, ID-3, iodothyronine 5′-deiodinase, Iodothyronine 5′-monodeiodinase, iodothyronine 5-deiodinase, iodothyronine deiodinase 2, iodothyronine deiodinase D2, iodothyronine inner ring monodeiodinase, iodothyronine outer ring monodeiodinase, L-thyroxine iodohydrolase (reducing), thyroxine 5-deiodinase, Thyroxine deiodinase, type 1 5′-deiodinase, type 1 deiodinase, Type 1 DI , type 1 iodothyronine deiodinase, type 2 5′-deiodinase, type 2 deiodinase, Type 2 DI , type 2 iodothyronine deiodinase, type 3 deiodinase, Type 3 DI , type I iodothyronine 5′-deiodinase, type I iodothyronine deiodinase, type I-like deiodinase, type II iodothyronine deiodinase, type II-like deiodinase, Type-I 5’deiodinase , Type-II 5’deiodinase , Type-III 5’deiodinase , types 1 iodothyronine selenodeiodinase, types 2 iodothyronine selenodeiodinase, XL-15 |
| EC Number | 1.21.99.4 |
| CAS Registry Number | 70712-46-8 |
| Comments | The enzyme activity has only been demonstrated in the direction of 5′-deiodination, which renders the thyroid hormone more active. The enzyme consists of type I and type II enzymes, both containing selenocysteine, but with different kinetics. For the type I enzyme the first reaction is a reductive deiodination converting the -Se-H group of the enzyme into an -Se-I group; the reductant then reconverts this into -Se-H, releasing iodide. Formerly EC 1.97.1.10 and EC 3.8.1.4. |
| Cofactor | |
| History | |
| Reactions | 3,5,3′-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH(2). |
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