tissue kallikrein EC#: 3.4.21.35; ChemWhat Code: 1380512
| Product Name | tissue kallikrein |
| Example Structure |  |
| Synonyms | bradykininogenase, callicrein, depot-Padutin, dilminal D, EC 3.4.21.8, EC 3.4.4.21, EMSP1, GK1, glandular kallikrein, glandular kallikrein 2, glandular kallikrein 24, glandular kallikrein-2, glumorin, HK1, hK10, hK11, hK13, hK14, hK3, hK5, hK6, hK8, HSCTE, HUK, K1, K2, Kailikang, Kal, kallidinogenase, kallikrein, kallikrein 1, kallikrein 24, kallikrein-related peptidase, kallikrein-related peptidase 10, kallikrein-related peptidase 2, kallikrein-related peptidase 7, kidney/pancreas/salivary gland kallikrein, kininogenase, kininogenin, KLK, KLK-L1 protein, KLK-L2 protein, KLK-L3, KLK-S3, KLK1, KLK10, KLK11, KLK3, KLK4, KLK5, KLK6, KLK7, KLK9, mK1, mK13, mK22, mK24, mK9, More, neurosin, onokrein P., P1 kallikrein, padreatin, padutin, pancreatic kallikrein, pancreatic/renal kallikrein, PPK, Prk, pro-renin-converting enzyme, prokallikrein, prostase, prostase/KLK-L1/ARM1/PRSS17, prostate specific antigen, protease M, PS kallikrein, PSA, PSA/KLK3, renal kallikrein, renal tissue kallikrein, RSGK-50, RUK, S01.160, S1 kallikrein, S2 kallikrein, S3 kallikrein, salivary kallikrein, SEV, skeletal muscle kallikrein, submandibular enzymatic vasoconstrictor, T-kininogenase, tissue kallidinogenase, tissue kallikrein, tissue kallikrein 1, tissue kallikrein 11, tissue kallikrein 4, tissue kallikrein 9, TK, trypsin-like serine protease, UKLK, urinary kallidinogenase, urinary kallikrein, urinary tissue kallikrein, urokallikrein, zyme |
| EC Number | 3.4.21.35 |
| CAS Registry Number | 9001/1/8 |
| Comments | Formed from tissue prokallikrein by activation with trypsin. In peptidase family?S1?(trypsin family). Formerly EC?3.4.4.21?and included in EC?3.4.21.8. A large number of tissue kallikrein-related sequences have been reported for rats [16] and mice [7], though fewer seem to exist in other mammals. The few that have been isolated and tested on substrates include mouse ¦Ã-renin (EC?3.4.21.54), submandibular proteinase A (formerly EC?3.4.21.40) [2, 15], epidermal growth-factor-binding protein, nerve growth factor ¦Ã-subunit, rat tonin [3, 4, 9], submaxillary proteinases A and B [10], T-kininogenase [18], kallikreins k7 and k8 [17] and human prostate-specific antigen (¦Ã-seminoprotein) [6]. |
| Cofactor | |
| History | |
| Reactions | Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. |
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