tRNA (adenine9-N1)-methyltransferase EC#: 2.1.1.218; ChemWhat Code: 1376457

Product Name tRNA (adenine9-N1)-methyltransferase
Example Structure Example Structure of tRNA (adenine9-N1)-methyltransferase EC#: 2.1.1.218
Synonyms TK0422p, Trm10p (ambiguous), tRNA m1A9 MTase, tRNA m1A9-methyltransferase, tRNA(m1G9/m1A9)-methyltransferase, tRNA(m1G9/m1A9)Mtase
EC Number 2.1.1.218
CAS Registry Number
Comments The enzyme from Sulfolobus acidocaldarius specifically methylates adenine9 in tRNA [1]. The bifunctional enzyme from Thermococcus kodakaraensis also catalyses the methylation of guanine9 in tRNA (cf. EC 2.1.1.221, tRNA (guanine9-N1)-methyltransferase).
Cofactor
History
Reactions S-adenosyl-L-methionine + adenine(9) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(9) in tRNA.

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