| Product Name |
tRNAPhe 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine37-N4]-methyltransferase |
| Example Structure |
![Example Structure of tRNAPhe 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine37-N4]-methyltransferase EC#: 2.1.1.282](/wp-content/uploads/enzyme-structure/2.1.1.282.jpg) |
| Synonyms |
TYW3, YGL050w |
| EC Number |
2.1.1.282 |
| CAS Registry Number |
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| Comments |
The enzyme is involved in the biosynthesis of hypermodified tricyclic bases found at position 37 of certain tRNAs. These modifications are important for translational reading-frame maintenance. The enzyme is found in all eukaryotes and in some archaea, but not in bacteria. The eukaryotic enzyme is involved in the biosynthesis of wybutosine. |
| Cofactor |
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| History |
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| Reactions |
S-adenosyl-L-methionine + 7-((3S)-(3-amino-3-carboxypropyl))-4- demethylwyosine(37) in tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)- (3-amino-3-carboxypropyl))wyosine(37) in tRNA(Phe). |
