tRNAPhe {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine37-N}-methoxycarbonyltransferase EC#: 2.3.1.231; ChemWhat Code: 1377054

Product Name tRNAPhe {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine37-N}-methoxycarbonyltransferase
Example Structure Example Structure of tRNAPhe {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine37-N}-methoxycarbonyltransferase EC#: 2.3.1.231
Synonyms tRNA-yW synthesizing enzyme 4, tRNA-yW synthesizing enzyme-4, TYW4
EC Number 2.3.1.231
CAS Registry Number
Comments The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs. The modification is important for translational reading-frame maintenance. In some species that produce hydroxywybutosine the enzyme uses 7-[2-hydroxy-3-amino-3-(methoxycarbonyl)propyl]wyosine37 in tRNAPhe as substrate. The enzyme also has the activity of EC 2.1.1.290, tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase [2].
Cofactor
History
Reactions S-adenosyl-L-methionine + 7-((3S)-3-amino-3- (methoxycarbonyl)propyl)wyosine(37) in tRNA(Phe) + CO(2) = S-adenosyl-L- homocysteine + wybutosine(37) in tRNA(Phe).

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