trypanothione-disulfide reductase EC#: 1.8.1.12; ChemWhat Code: 1374682
| Product Name | trypanothione-disulfide reductase |
| Example Structure |  |
| Synonyms | EC 1.6.4.8, N(1),N(8)-bis(glutathionyl)spermidine reductase, NADPH2:trypanothione oxidoreductase, TCDM_11669, TPR, TR, trypanothione disulfide reductase, trypanothione reductase, trypanothione-disulfide reductase, TryR |
| EC Number | 1.8.1.12 |
| CAS Registry Number | 102210-35-5 |
| Comments | Trypanothione disulfide is the oxidized form of N1,N8-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. The enzyme from Crithidia fasciculata is a flavoprotein (FAD), whose activity is dependent on a redox-active cystine at the active centre (cf. EC 1.8.1.7, glutathione-disulfide reductase). |
| Cofactor | FAD |
| History | |
| Reactions | Trypanothione + NADP(+) = trypanothione disulfide + Nadph. |
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