tryptophan 5-halogenase EC#: 1.14.19.58; ChemWhat Code: 1375823
| Product Name | tryptophan 5-halogenase |
| Example Structure |  |
| Synonyms | halogenase, mibH, pyrH, sttH, trp-5-halogenase |
| EC Number | 1.14.19.58 |
| CAS Registry Number | |
| Comments | A flavin-dependent halogenase. The enzyme from the bacterium Streptomyces rugosporus catalyses halogenation of the C-5 position of tryptophan during the biosynthesis of the antibiotic compound pyrroindomycin B. It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion. The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate. cf. EC 1.14.19.59, tryptophan 6-halogenase and EC 1.14.19.9, tryptophan 7-halogenase. |
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