tryptophan 7-halogenase EC#: 1.14.19.9; ChemWhat Code: 1375773
| Product Name | tryptophan 7-halogenase |
| Example Structure |  |
| Synonyms | FAD-dependent halogenase, flavin-dependent halogenase, flavin-dependent tryptophan halogenase, halogenase, KtzQ, L-tryptophan-7-halogenase, PrnA, RebH, Trp 7-hal, Trp halogenase, Trp-7-Hal, Trp-7-halogenase |
| EC Number | 1.14.19.9 |
| CAS Registry Number | |
| Comments | A flavin-dependent halogenase. The enzyme from the bacterium Lechevalieria aerocolonigenes catalyses the initial step in the biosynthesis of rebeccamycin [2]. It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion. The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate. Also acts on bromide ion. cf. EC 1.14.19.58, tryptophan 5-halogenase, and EC 1.14.19.59, tryptophan 6-halogenase. |
| Cofactor | |
| History | |
| Reactions | Tryptophan + FADH(2) + chloride + O(2) + H(+) = 7-chloro-L-tryptophan + Fad + 2 H(2)O. |
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