type I site-specific deoxyribonuclease EC#: 3.1.21.3; ChemWhat Code: 1379733

Product Name type I site-specific deoxyribonuclease
Example Structure Example Structure of type I site-specific deoxyribonuclease EC#: 3.1.21.3
Synonyms adenosine triphosphate-dependent deoxyribonuclease, ATP-dependent deoxyribonuclease, ATP-dependent DNase, BsaHI restriction-modification system, C.PvuII, CfrAI, deoxyribonuclease (ATP- and S-adenosyl-L-methionine dependent), deoxyribonuclease (ATP-dependent), DNase, EC 3.1.23, EC 3.1.24, EC 3.1.4.33, Eco377I, Eco394I, Eco585I, Eco646I, Eco777I, Eco826I, Eco851I, Eco912I, EcoA0ORF42P, EcoAI, EcoAO83I, EcoB, EcoBI, EcoDI, EcoDXXI, EcoEI, EcoGIV, EcoK, EcoKI, EcoKI type I DNA restriction enzyme, EcoKI type I restriction-modification system, EcoprrI, EcoR, EcoR124, EcoR124/3I, EcoR124I, EcoR124II, EcoRII modification enzyme, EcoRII RM gene complex, EcoRII system, endodeoxyribonuclease, Esp1396I, exodeoxyribonuclease, H91_orf206, H91_orf376, HpyAXII restriction-modification system, HsdM, HsdR, hsdS, KpnBI, More, MpnORFDAP, MpnORFDBP, nuclease, deoxyribo-, nuclease, deoxyribo-, ATP-dependent, PspGI endonuclease, PspGI restriction-modification system, R. BsaHI, R.EcoAI, R.EcoEI, R.EcoKI, R.EcoR124I restriction endonuclease, R.EcoR124II, R.EcoR124INT, R.HpyAXII, R.PspGI, REase, RecoK, restriction-modification system, Sau1, Sau1 type I restriction-modification system, Sau1 Type I RM system, SauMW2I, SauMW2II, SauN315I, SauN315II, StyLTIII, StySBI, StySEAI, StySGI, StySJI, StySKI, StySPI, StySQI, type I R-M enzyme, type I R-M system, type I restriction enzyme, type I restriction modification enzyme, type I restriction-modification enzyme, type I restriction-modification system, type I restriction-modification system EcoR124I, type IB restriction enzyme, type II R-M system, type II restriction-modification system
EC Number 3.1.21.3
CAS Registry Number 37263-09-5
Comments This is a large group of enzymes which, together with those now listed as EC?3.1.21.4?(type II site-specific deoxyribonuclease) and EC?3.1.21.5?(type III site-specific deoxyribonuclease), were previously listed separately in sub-subclasses EC?3.1.23?and EC?3.1.24. They have an absolute requirement for ATP (or dATP) and?S-adenosyl-L-methionine. They recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. They are multifunctional proteins that also catalyse the reactions of EC?2.1.1.72?[site-specific DNA-methyltransferase (adenine-specific)] and EC?2.1.1.73?[site-specific DNA-methyltransferase (cytosine-specific)], with similar site specificity. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available at http://rebase.neb.com/rebase/.
Cofactor
History
Reactions Endonucleolytic cleavage of Dna to give random double-stranded fragments with terminal 5′-phosphates; Atp is simultaneously hydrolyzed.

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