| Product Name |
UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase |
| Example Structure |
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| Synonyms |
2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerase, UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerases, UDP-alpha-D-GlcNAc3NAcA 2-epimerase, UDP-GlcNAc3NAcA 2-epimerase, WbpI, WlbD |
| EC Number |
5.1.3.23 |
| CAS Registry Number |
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| Comments |
This enzyme participates in the biosynthetic pathway for UDP-¦Á-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-¦Á-D-mannuronic acid), an important precursor of the B-band lipopolysaccharide of?Pseudomonas aeroginosa?serotype O5 and of the band-A trisaccharide of?Bordetella pertussis, both important respiratory pathogens [1]. The enzyme is highly specific as UDP-¦Á-D-GlcNAc, UDP-¦Á-D-GlcNAcA (UDP-2-acetamido-2-deoxy-¦Á-D-glucuronic acid) and UDP-¦Á-D-GlcNAc3NAc (UDP-2,3-diacetamido-2,3-dideoxy-¦Á-D-glucose) cannot act as substrates [1]. |
| Cofactor |
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| History |
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| Reactions |
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3- diacetamido-2,3-dideoxy-alpha-D-mannuronate. |
