UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase EC#: 1.1.1.335; ChemWhat Code: 1373450
| Product Name | UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase |
| Example Structure |  |
| Synonyms | |
| EC Number | 1.1.1.335 |
| CAS Registry Number | |
| Comments | This enzyme participates in the biosynthetic pathway for UDP-¦Á-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-¦Á-D-mannuronic acid), an important precursor of B-band lipopolysaccharide. The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus thermophilus form a complex with the the enzyme catalysing the next step the pathway (EC 2.6.1.98, UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase). The enzyme also possesses an EC 1.1.99.2 (2-hydroxyglutarate dehydrogenase) activity, and utilizes the 2-oxoglutarate produced by EC 2.6.1.98 to regenerate the tightly bound NAD+. The enzymes from Bordetella pertussis and Chromobacterium violaceum do not bind NAD+ as tightly and do not require 2-oxoglutarate to function. |
| Cofactor | |
| History | |
| Reactions | UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate + NAD(+) = UDP-2- acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + Nadh. |
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