UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase EC#: 6.3.2.13; ChemWhat Code: 1383737
| Product Name | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase |
| Example Structure |  |
| Synonyms | amide ligase, Diaminopimelic-adding enzyme, mDAP ligase, Meso-diaminopimelate-adding enzyme, Mur ligase, MurE, MurE synthetase, MurEEr, peptidoglycan MurE ligase, Synthetase, uridine diphospho-N-acetylmuramoylalanyl-D-glutamyl-meso-2,6-diaminopimelate, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase, UDP-N-acetylmuramyl tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase, UDPMurNAc-L-alanyl-D-glutamate:mDAP ligase (ADP-forming), Uridine diphosphate N-acetylmuramyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate ligase, Uridine-diphosphate-N-acetylmuramyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate synthetase |
| EC Number | 6.3.2.13 |
| CAS Registry Number | 9075/9/6 |
| Comments | Involved in the synthesis of a cell-wall peptide. This enzyme adds diaminopimelate in Gram-negative organisms and in some Gram-positive organisms; in others EC?6.3.2.7?(UDP-N-acetylmuramoyl-L-alanyl-D-glutamate¡ªL-lysine ligase) adds lysine instead. It is the amino group of the?L-centre of the diaminopimelate that is acylated. |
| Cofactor | |
| History | |
| Reactions | Atp + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + meso-2,6- diaminoheptanedioate = Adp + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L- alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate. |
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