| Product Name |
UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase |
| Example Structure |
 |
| Synonyms |
AbMurF, ATP-dependent UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase, D-Ala-D-Ala-adding enzyme, More, MurF, MurF1, Synthetase, uridine diphosphoacetylmuramoylpentapeptide, UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase, UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase, UDPacetylmuramoylpentapeptide synthetase, Uridine diphosphoacetylmuramoylpentapeptide synthetase |
| EC Number |
6.3.2.10 |
| CAS Registry Number |
9023-60-3 |
| Comments |
Involved with EC?6.3.2.4?(D-alanine¡ªD-alanine ligase), EC?6.3.2.7?(UDP-N-acetylmuramoyl-L-alanyl-D-glutamate¡ªL-lysine ligase) or EC?6.3.2.13?(UDP-N-acetylmuramoylalanyl-D-glutamate¡ª2,6-diaminopimelate ligase), EC?6.3.2.8?(UDP-N-acetylmuramate¡ªL-alanine ligase) and EC?6.3.2.9?(UDP-N-acetylmuramoylalanine¡ªD-glutamate ligase) in the synthesis of a cell-wall peptide. This enzyme also catalyses the reaction when the C-terminal residue of the tripeptide is?meso-2,4-diaminoheptanedioate (acylated at its?L-centre), linking the?D-Ala¡ªD-Ala to the carboxy group of the?L-centre. This activity was previously attributed to EC?6.3.2.15, which has since been deleted. |
| Cofactor |
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| History |
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| Reactions |
Atp + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl- D-alanine = Adp + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D- glutamyl-L-lysyl-D-alanyl-D-alanine. |
