UDP-sugar diphosphatase EC#: 3.6.1.45; ChemWhat Code: 1381603

Product Name UDP-sugar diphosphatase
Example Structure Example Structure of UDP-sugar diphosphatase EC#: 3.6.1.45
Synonyms 5′-nucleotidase/UDP-sugar hydrolase, hydrolase, uridine diphosphoglucose (Escherichia coli precursor reduced), hydrolase, uridine diphosphoglucose (Escherichia coli reduced), hydrolase, uridine diphosphoglucose (Salmonella typhimurium clone pAGS5 gene ushB isoenzyme reduced), hydrolase, uridine diphosphoglucose (Salmonella typhimurium gene ushA0 isoenzyme precursor reduced), hydrolase, uridine diphosphoglucose (Salmonella typhimurium gene ushA0 isoenzyme reduced), nucleosidediphosphate-sugar diphosphatase, nucleosidediphosphate-sugar pyrophosphatase, Nudix hydrolase-like nucleotide hydrolase, toxin A, toxin B, UDP-glucose pyrophosphatase, UDP-sugar diphosphatase, UDP-sugar hydrolase, UDP-sugar pyrophosphatase, UDPG pyrophosphatase, UGPPase, UshA, UshB protein
EC Number 3.6.1.45
CAS Registry Number 103716-25-2;103716-26-3;57127-20-5
Comments A divalent cation is required for activity. UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar?Km?values but much lower maximum velocities. Thus, this enzyme has a specificity distinct from that of ADP-sugar diphosphatase (EC?3.6.1.21). Some but not all enzymes of this class also appear to have 5′-nucleotidase (see EC?3.1.3.5) activity.
Cofactor divalent cation
History
Reactions UDP-sugar + H(2)O = Ump + alpha-D-aldose 1-phosphate.

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