Ulp1 peptidase EC#: 3.4.22.68; ChemWhat Code: 1380814
| Product Name | Ulp1 peptidase |
| Example Structure |  |
| Synonyms | C48.001, ELS1, ESD4, PFL1635w, SENP, SENP1, SENP2, SENP6, SENP7, small ubiquitin-like modifier protease, Small ubiquitin-related modifier protein 1 conjugate proteinase, Smt3-protein conjugate proteinase, SMT3IP1, SMT3IP1/SENP3, SUMO deconjugating protease, SUMO protease, SUMO protease 1, SUMO(Smt3)-specific protease, SUMO-specific protease, SUMO-specific protease 2, Ubl-specific protease 1, Ulp1, Ulp1 endopeptidase, Ulp1 protease |
| EC Number | 3.4.22.68 |
| CAS Registry Number | |
| Comments | The enzyme from?Saccharomyces cerevisiae?can also recognize small ubiquitin-like modifier 1 (SUMO-1) from human as a substrate in both SUMO-processing (¦Á-linked peptide bonds) and SUMO-deconjugation (¦Å-linked peptide bonds) reactions [1,2,3]. Ulp1 has several functions, including an essential role in chromosomal segregation and progression of the cell cycle through the G2/M phase of the cell cycle. Belongs in peptidase family?C48. |
| Cofactor | |
| History | |
| Reactions | Hydrolysis of the alpha-linked peptide bond in the sequence Gly- Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature Sumo and the lysine epsilon-amino group of the target protein. |
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