uridine-5′-phosphate dioxygenase EC#: 1.14.11.49; ChemWhat Code: 1375142

Product Name uridine-5′-phosphate dioxygenase
Example Structure Example Structure of uridine-5'-phosphate dioxygenase EC#: 1.14.11.49
Synonyms alpha-ketoglutarate:UMP dioxygenase, alpha-KG:UMP dioxygenase, LIPL, UMP:alpha-ketoglutarate dioxygenase, uridine-5-monophosphate alpha-ketoglutarate dioxygenase
EC Number 1.14.11.49
CAS Registry Number
Comments The enzyme catalyses a net dephosphorylation and oxidation of UMP to generate 5′-dehydrouridine, the first intermediate in the biosynthesis of the unusual aminoribosyl moiety found in several C7-furanosyl nucleosides such as A-90289s, caprazamycins, liposidomycins, muraymycins and FR-900453. Requires Fe2+.
Cofactor Fe2+
History
Reactions Ump + 2-oxoglutarate + O(2) = 5′-dehydrouridine + succinate + CO(2) + phosphate.

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