valine N-monooxygenase EC#: 1.14.14.38; ChemWhat Code: 1375546

Product Name valine N-monooxygenase
Example Structure Example Structure of valine N-monooxygenase EC#: 1.14.14.38
Synonyms CYP79D1, CYP79D2, CYP79D3, CYP79D4, N-hydroxylating cytochrome P450, valine N-monooxygenase
EC Number 1.14.14.38
CAS Registry Number
Comments A cytochrome P-450 (heme-thiolate) protein. This enzyme catalyses two successive N-hydroxylations of L-valine, the committed step in the biosynthesis of the cyanogenic glucoside linamarin in Manihot esculenta (cassava). The product of the two hydroxylations, N,N-dihydroxy-L-valine, is labile and undergoes dehydration and decarboxylation that produce the (E) isomer of the oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. The enzyme can also accept L-isoleucine as substrate, with a lower activity. It is different from EC 1.14.14.39, isoleucine N-monooxygenase, which prefers L-isoleucine.
Cofactor heme-thiolate
History
Reactions L-valine + 2 O(2) + 2 [reduced NADPH–hemoprotein reductase] = (E)-2- methylpropanal oxime + 2 [oxidized NADPH–hemoprotein reductase] + CO(2) + 3 H(2)O.

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