valine N-monooxygenase EC#: 1.14.14.38; ChemWhat Code: 1375546
Product Name | valine N-monooxygenase |
Example Structure | |
Synonyms | CYP79D1, CYP79D2, CYP79D3, CYP79D4, N-hydroxylating cytochrome P450, valine N-monooxygenase |
EC Number | 1.14.14.38 |
CAS Registry Number | |
Comments | A cytochrome P-450 (heme-thiolate) protein. This enzyme catalyses two successive N-hydroxylations of L-valine, the committed step in the biosynthesis of the cyanogenic glucoside linamarin in Manihot esculenta (cassava). The product of the two hydroxylations, N,N-dihydroxy-L-valine, is labile and undergoes dehydration and decarboxylation that produce the (E) isomer of the oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. The enzyme can also accept L-isoleucine as substrate, with a lower activity. It is different from EC 1.14.14.39, isoleucine N-monooxygenase, which prefers L-isoleucine. |
Cofactor | heme-thiolate |
History | |
Reactions | L-valine + 2 O(2) + 2 [reduced NADPH–hemoprotein reductase] = (E)-2- methylpropanal oxime + 2 [oxidized NADPH–hemoprotein reductase] + CO(2) + 3 H(2)O. |
Buy Reagent | |
No reagent supplier? | Send quick inquiry to ChemWhat |
Want to be listed here as a reagent supplier? (Paid service) | Click here to contact ChemWhat |
Approved Manufacturers | |
Want to be listed as an approved manufacturer (Requires approvement)? | Please download and fill out this form and send back to approved-manufacturers@chemwhat.com |
Contact Us for Other Help | |
Contact us for other information or services | Click here to contact ChemWhat |