very-long-chain 3-oxoacyl-CoA reductase EC#: 1.1.1.330; ChemWhat Code: 1373444

Product Name very-long-chain 3-oxoacyl-CoA reductase
Example Structure Example Structure of very-long-chain 3-oxoacyl-CoA reductase EC#: 1.1.1.330
Synonyms 3-ketoacyl-CoA reductase, beta-ketoacyl-CoA reductase, IFA38, KCR, KCR1, KCR2, KCR3, very-long-chain 3-ketoacyl-CoA reductase, very-long-chain beta-ketoacyl-CoA reductase, ybr159, YBR159w
EC Number 1.1.1.330
CAS Registry Number
Comments The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. The enzyme is active with substrates with chain length of C16 to C34, depending on the species. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase.
Cofactor
History
Reactions A very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + Nadph.

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