| Synonyms |
3-ketoacyl CoA synthase, 3-ketoacyl-CoA synthase, acyl-CoA elongase, At1g01120, At2g26640, beta-ketoacyl CoA synthase, beta-ketoacyl-CoA synthase, CER2-LIKE1, CER2-LIKE2, CER26, CER26L, CER6, CER60, condensing enzyme, Cut1, CUT1L, ECERIFERUM 26, ECERIFERUM 26-like, ELO, ELo1, Elo1p, Elo2p, Elo3p, EloA, ELOVL1, ELOVL5, Elovl6, ELOVL7, FA elongase, FAE1, FAE1 beta-ketoacyl-CoA synthase, FAE1 KCS, Fatty acid elongase, fatty acid elongase 1, fatty acid elongation 1, fatty acid elongation1, KCS, Kcs1, KCS17, KCS2, KCS2/DAISY, KCS20, microsomal fatty acid elongase, Onion2, Os03g0220100, Os10 g0416200, seed-specific condensing enzyme, very-long-chain fatty acid condensing enzyme, very-long-chain fatty acid-condensing enzyme, VLCFA condensing enzyme, VLCFA elongase |
| Comments |
This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids [6,7]. For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate [5], while CER6 from the same plant prefers substrates with chain length of C22 to C32 [4,8]. cf. EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase. |
