| Product Name |
vitamin D 1,25-hydroxylase |
| Example Structure |
 |
| Synonyms |
CYP105A1, cytochrome P450SU-1, Streptomyces griseolus cytochrome P450SU-1, vitamin D3 dihydroxylase |
| EC Number |
1.14.15.22 |
| CAS Registry Number |
|
| Comments |
A P-450 (heme-thiolate) enzyme found in the bacterium Streptomyces griseolus. cf. EC 1.14.14.24, vitamin D 25-hydroxylase and EC 1.14.15.18, calcidiol 1-monooxygenase. |
| Cofactor |
|
| History |
|
| Reactions |
(1) Calciol + O(2) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) = calcidiol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O. (2) Calcidiol + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = calcitriol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O. |
