vitamin D 1,25-hydroxylase EC#: 1.14.15.22; ChemWhat Code: 1375712

Product Name vitamin D 1,25-hydroxylase
Example Structure Example Structure of vitamin D 1,25-hydroxylase EC#: 1.14.15.22
Synonyms CYP105A1, cytochrome P450SU-1, Streptomyces griseolus cytochrome P450SU-1, vitamin D3 dihydroxylase
EC Number 1.14.15.22
CAS Registry Number
Comments A P-450 (heme-thiolate) enzyme found in the bacterium Streptomyces griseolus. cf. EC 1.14.14.24, vitamin D 25-hydroxylase and EC 1.14.15.18, calcidiol 1-monooxygenase.
Cofactor
History
Reactions (1) Calciol + O(2) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) = calcidiol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O. (2) Calcidiol + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = calcitriol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O.

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