vitamin D3 24-hydroxylase EC#: 1.14.15.16; ChemWhat Code: 1375705
| Product Name | vitamin D3 24-hydroxylase |
| Example Structure |  |
| Synonyms | 1,25-(OH)2D3-24-hydroxylases, 1,25-dihydroxyvitamin D3 24-hydroxylase, 1alpha,25-dihydroxyvitamin D3 24-hydroxylase, 24-hydroxylase, 24-OHase, 24OHase, 25-hydroxyvitamin D-24-hydroxylase, 25-hydroxyvitamin D3-24-hydroxylase, 25-OH-D3-24-hydroxylase, CYP24A1, cytochrome P450 24A1, P450cc24, vitamin D 24-hydroxylase, vitamin D-24-hydroxylase |
| EC Number | 1.14.15.16 |
| CAS Registry Number | |
| Comments | This mitochondrial cytochrome P-450 enzyme requires adrenodoxin. The enzyme can perform up to 6 rounds of hydroxylation of the substrate calcitriol leading to calcitroic acid. The human enzyme also shows 23-hydroxylating activity leading to 1,25 dihydroxyvitamin D3-26,23-lactone as end product while the mouse and rat enzymes do not. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase. |
| Cofactor | heme-thiolate |
| History | |
| Reactions | (1) Calcitriol + 2 reduced adrenodoxin + 2 H(+) + O(2) = calcitetrol + 2 oxidized adrenodoxin + H(2)O. (2) Calcidiol + 2 reduced adrenodoxin + 2 H(+) + O(2) = secalciferol + 2 oxidized adrenodoxin + H(2)O. |
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