In peptidase family?A1?of pepsin, and weakly inhibited by pepstatin. Can partially substitute for kexin in a deficient strain of yeast. The homologous product of theMkc7?gene?(Saccharomyces cerevisiae)?has similar catalytic activity and has been termed yapsin 2 [2].
Cofactor
History
Reactions
Hydrolyzes various precursor proteins with Arg or Lys in P1, and commonly Arg or Lys also in P2. The P3 amino acid is usually non-polar, but otherwise additional basic amino acids are favorable in both non- prime and prime positions.
