Recombinant Canine Interleukin-8/CXCL8 (rCaIL-8/CXCL8, P41324, 403850) CAS#: 131-08-1816; ChemWhat Code: 1404354

Official Full Name Recombinant Canine Interleukin-8/CXCL8 (rCaIL-8/CXCL8)
Squence Squence of Recombinant Canine Interleukin-8/CXCL8
Synonyms (Ser-IL-8)72, GCP/IL-8 protein I, IL8/NAP1 form III, LYNAP, MDNCF-c, NAF
Accession Number P41324
GeneID 403850
Summary Interleukin-8 (IL-8) is encoded by the IL8 gene andproduced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles. There are many receptors capable to bind IL-8, the most affinity to IL-8 are receptors CXCR1, and CXCR2. As a member of the CXC chemokine family, function of IL-8 is the induction of chemotaxis in its target cells, like neutrophil granulocytes, basophils, and T-cells. . IL-8 is often associated with inflammation and has been cited as a proinflammatory mediator in gingivitis and psoriasis.
Source Escherichia coli.
Molecular Weight Approximately 9.1 kDa, a single non-glycosylated polypeptide chain containing 79 amino acids.
Biological Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human CXCR2 transfected murine BaF3 cells is in a concentration range of 0.15-0.75 ng/ml.
Appearance Sterile filtered white lyophilized (freeze-dried) powder.
Formulation Lyophilized from a 0.2 um filtered concentrated solution in 2 × PBS, pH 7.4.
Endotoxin Less than 1 EU/ug of rCaIL-8/CXCL8 as determined by LAL method.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Stability and Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
SDS-PAGE SDS-PAGE of Recombinant Canine Interleukin-8/CXCL8
Safety Data Sheet (SDS) Download Click to download
Technical Data Sheet (TDS) Download Click to download

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