Recombinant Human Interferon-alpha2b, Yeast (rHuIFN-alpha2b,Yeast, P01563, 3440) CAS#: 106-0425-1816

Official Full Name Recombinant Human Interferon-alpha2b, Yeast (rHuIFN-alpha2b,Yeast)
Squence Squence of Recombinant Human Interferon-alpha2b, Yeast
Amino Acid Sequence CDLPQTHSLG SRRTLMLLAQ MRRISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE
Synonyms
Accession Number P01563
GeneID 3440
Summary IFN-alphas are proteins secreted by leukocyte. They are mainly involved in innate immune response against viral infection. The IFN-alpha family has 13 subtypes and 23 different variants. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-alpha subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-alpha subtypes differ in their sequences at only one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxy-terminal end.
Source Yeast
Molecular Weight Approximately 19.3 kDa, a single polypeptide chain containing 165 amino acids.
Biological Activity Fully biologically active when compared to standard. The specific activity determined by an anti-viral assay is no less than 1.6 × 108 IU/mg.
Appearance Sterile filtered white lyophilized (freeze-dried) powder.
Formulation Lyophilized from a 0.2 um filtered solution in PBS, pH 7.4, with 0.02 % Tween-20.
Endotoxin Less than 0.1 EU/ug of rHuIFN-α2b, Yeast as determined by LAL method.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Stability and Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
References
SDS-PAGE SDS-PAGE of Recombinant Human Interferon-alpha2b, Yeast
Safety Data Sheet (SDS) Download Click to download
Technical Data Sheet (TDS) Download Click to download

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