ADP-dependent NAD(P)H-hydrate dehydratase EC#: 4.2.1.136; ChemWhat Code: 1382443

Product Name ADP-dependent NAD(P)H-hydrate dehydratase
Example Structure Example Structure of ADP-dependent NAD(P)H-hydrate dehydratase EC#: 4.2.1.136
Synonyms ADP-dependent (S)-NAD(P)H-hydrate dehydratase, ADP/ATP-dependent NAD(P)H-hydrate dehydratase, BSU38720, Carkd, More, NAD(P)H-hydrate dehydratase, NAD(P)HX dehydratase, NADHX dehydratase, NNRD, Tm0922, YjeF, YKL151C, YxkO
EC Number 4.2.1.136
CAS Registry Number
Comments Acts equally well on hydrated NADH and hydrated NADPH. NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers. The enzyme from bacteria consists of two domains, one of which acts as an NAD(P)H-hydrate epimerase that interconverts the two isomers to a 60:40 ratio (cf. EC?5.1.99.6), while the other catalyses the dehydration. Hence the enzyme can restore the complete mixture of isomers into NAD(P)H. The enzyme has no activity with ATP, contrary to the enzyme from eukaryotes (cf. EC?4.2.1.93, ATP-dependent NAD(P)H-hydrate dehydratase).
Cofactor
History
Reactions (1) Adp + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine- dinucleotide = Amp + phosphate + nadh. (2) Adp + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine- dinucleotide phosphate = Amp + phosphate + nadph.

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