Anti-Vitamin B9 (Vitamin B9, VB9, Folic Acid, CAS#: 59-30-3) antibody

AntigenDescriptionProperties
Safety InformationImagesOther Info

Antigen

NameVitamin B9
Synonyms5 Methyl THFA; 5 Methyltetrahydrofolate; Folate; Tetrahydrofolate; Tetrahydrofolic acid; THFA; Folic Acid; 59-30-3

Description

NameAnti-Vitamin B9 antibody
Monoclonal Folic Acid antibody, Anti-Folic Acid antibody, Folate antibody, Vitamin M antibody, Vitamin B9 antibody, Vitamin Bc antibody, Folacin antibody, Pteroyl-L-glutamic acid antibody, Pteroyl-L-glutamate antibody
HostMouse; Goat; Rabbit
Antibody Product Type  Primary
Conjugate Unconjugated; Biotin; APC; Alkaline Phosphatase (AP); FITC; HRP; PE
SpecifityRecognizes free folic acid, otherwise known as Vitamin B9, a water-soluble vitamin found naturally in food. Folic acid is essential for production and maintenance of new cells particularly during pregnancy and infancy. Folate (the anion form of folic acid) functions in the synthesis of DNA bases, and folate deficiency limits cell division leading to megaloblastic anemia. Folic acid is particularly important just before and just after conception, to help protect against neural tube defects such as spina bifida.
ApplicationELISA; Immunohistochemistry (IHC); Western Blotting (WB); Immunofluorescence (fixed cells) (IF/ICC); Immunoprecipitation (IP); Cell-ELISA (cELISA); Immunoassay (IA); Immunocytochemistry (ICC)

Properties

FormLiquid/Lyophilized
HandlingThe antibody solution should be gently mixed before use.
Storage ConditionStore at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for a year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
ClonalityMonoclonal/Polyclonal
IsotypeIgG

Safety Information

RIDADRNONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable

Images

Vitamin B9 / Folic acid ELISA KitFolic acid Vitamin B9 ELISA Kit
Western Blot (WB) Experiment Monoclonal Anti-Folic Acid antibody produced in mouse

Other Info

About the antigenFolic acid and Folate (the anion form) are forms of a water-soluble B vitamin. These occur naturally in food and can also be taken as supplements. The biologically active form of folic acid is tetrahydrofolic acid (THFA), which is derived by the 2-step reduction of folate involving dihydrofolate reductase. THFA plays a key role in the transfer of 1-carbon units (such as methyl, methylene, and formyl groups) to the essential substrates involved in the synthesis of DNA, RNA, and proteins. More specifically, THFA is involved with the enzymatic reactions necessary to synthesis of purines, thymidine, and amino acids. Manifestations of folate deficiency thereafter, not surprisingly, would involve impairment of cell division, accumulation of possibly toxic metabolites such as homocysteine, and impairment of methylation reactions involved in the regulation of gene expression, thus increasing neoplastic risks. Folate is necessary for the production and maintenance of new cells. This is especially important during periods of rapid cell division and growth such as infancy and pregnancy when a deficiency can result in neural tube defects. In folate deficiency the bone marrow is affected as it is a site of rapid cell turnover. Large red blood cells called megaloblasts are produced, resulting in megaloblastic anemia.

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