| Synonyms |
3-ketoacyl acyl carrier protein synthase III, 3-ketoacyl carrier protein synthase III, 3-ketoacyl-(acyl carrier protein) synthase IIIA, 3-ketoacyl-(acyl carrier protein) synthase IIIB, 3-ketoacyl-ACP synthase III, 3-ketoacyl-acyl carrier protein synthase III, 3-ketoacyl-acyl-carrier protein synthase III, 3-oxoacyl-acyl carrier protein synthase III, 3-oxoacyl-[acyl-carrier-protein] synthase III, acetoacetyl-ACP synthase, acetyl-CoA:ACP transacylase, ACO synthase III, ACP synthase III, beta-ketoacyl (acyl carrier protein) synthase III, beta-ketoacyl acyl carrier protein synthase III, beta-ketoacyl acyl-carrier protein synthase III, beta-ketoacyl-(ACP) synthase III, beta-ketoacyl-(acyl-carrier-protein) synthase III, beta-ketoacyl-ACP III, beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP synthase III, beta-ketoacyl-ACP-synthase III, beta-ketoacyl-acyl carrier protein (ACP) synthase III, beta-ketoacyl-acyl carrier protein synthase III, beta-ketoacyl-[acyl-carrier protein (ACP)] synthase III, beta-ketoacyl-[acyl-carrier-protein] synthase III, beta-ketoacyl:acyl carrier protein synthase III, beta-ketoacylacylcarrier protein synthase III, beta-ketobutyryl-ACP synthase, DpsC, ecFabH, ecKAS III, efFabH, FabH, fatty acid biosynthesis, enzyme H, fatty acid synthase type II condensing enzyme, hiFabH, initiation ketosynthase, JcKAS III, KAS III, KAS IIIA, KAS IIIB, KAS-III, KAS3a, KAS3b, KASIII, mtFabH, nmFabH, paFabH, saFabH, short-chain condensing enzyme, spFabH, spyFabH, [acyl-carrier-protein] synthase III |
| Comments |
Involved in the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. In contrast to EC 2.3.1.41 (¦Â-ketoacyl-ACP synthase I) and EC 2.3.1.179 (¦Â-ketoacyl-ACP synthase II), this enzyme specifically uses CoA thioesters rather than acyl-ACP as the primer [1]. In addition to the above reaction, the enzyme can also catalyse the reaction of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, but to a much lesser extent [1]. The enzyme is responsible for initiating both straight- and branched-chain fatty-acid biosynthesis [2], with the substrate specificity in an organism reflecting the fatty-acid composition found in that organism [2,5]. For example, Streptococcus pneumoniae, a Gram-positive bacterium, is able to use both straight- and branched-chain (C4¡ªC6) acyl-CoA primers [3] whereas Escherichia coli, a Gram-negative organism, uses primarily short straight-chain acyl CoAs, with a preference for acetyl-CoA [4,5]. |
![Example Structure of beta-ketoacyl-[acyl-carrier-protein] synthase III EC#: 2.3.1.180](/wp-content/uploads/enzyme-structure/2.3.1.180.jpg)