Geneticin CAS#: 108321-42-2; ChemWhat Code: 18950
Identification
| Product Name | Geneticin |
| IUPAC Name | (2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid |
| Molecular Structure | |
| CAS Registry Number | 108321-42-2 |
| EINECS Number | No data available |
| MDL Number | MFCD28168024 |
| Beilstein Registry Number | No data available |
| Synonyms | (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid G-418 sulfate; G-418 (disulfate); G-418 disulfate; G418 Disulfate; G 418 disulfate salt; MFCD05664725; (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid; Antibiotic G-418, sulfate (salt); G-418 disulfate?; ANTIBIOTIC G-418 SULFATE; AKOS024457991; G418 disulfate, Cell Culture Reagent; HY-17561; (2R,3S,4R,5R,6S)-5-Amino-6-(((1R,2S,3S,4R,6S)-4,6-diamino-3-(((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-2-((R)-1-hydroxyethyl)tetrahydro-2H-pyran-3,4-diol bis(sulfate); (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]-5-methyl-4-(methylamino)tetrahydropyran-3,5-diol;sulfuric acid; (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]-2-oxanyl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid; (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-bis(azanyl)-3-[(2S,3R,4R,5S,6R)-3-azanyl-4,5-bis(oxidanyl)-6-[(1R)-1-oxidanylethyl]oxan-2-yl]oxy-2-oxidanyl-cyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid |
| Molecular Formula | C20H44N4O18S2 |
| Molecular Weight | 692.702 |
| InChI | InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;21-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2(H2,1,2,3,4)/t6-,7+,8-,9-,10-,11+,12+,13-,14-,15-,16+,17-,18-,19-,20+;;/m1../s1 |
| InChI Key | UHEPSJJJMTWUCP-DHDYTCSHSA-N |
| Canonical SMILES | CN[C@@H]1C@@HC@@HO)C@@HC@H[C@H]3N)C@@HC[C@H]2N)OC[C@]1(C)O.O=S(=O)(O)O.O=S(=O)(O)O |
| Patent Information |
| No data available |
Physical Data
| Appearance | White powder |
| Solubility | H2O:50 mg/mL |
| Flash Point | No data available |
| Refractive index | No data available |
| Sensitivity | No data available |
Spectra
| No data available |
Route of Synthesis (ROS)
| No data available |
Safety and Hazards
| Pictogram(s) |   |
| Signal | Danger |
| GHS Hazard Statements | H315 (25%): Causes skin irritation [Warning Skin corrosion/irritation] H317 (93.1%): May cause an allergic skin reaction [Warning Sensitization, Skin] H319 (25%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H334 (81.9%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory] H360 (13.9%): May damage fertility or the unborn child [Danger Reproductive toxicity] Information may vary between notifications depending on impurities, additives, and other factors. |
| Precautionary Statement Codes | P203, P233, P260, P261, P264, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P318, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| SDS Download | English Version |
Other Data
| Transportation | NONH for all modes of transport |
| Under the room temperature and away from light | |
| HS Code | No data available |
| Storage | Under the room temperature and away from light |
| Shelf Life | 2 years |
| Market Price | USD |
| Use Pattern |
| Geneticin CAS#: 108321-42-2, an aminoglycoside antibiotic, is an inhibitor of 80 S ribosomes extension. It can block polypeptide synthesis by inhibiting the extension step in both prokaryotic and eukaryotic cells. It blocks polypeptide synthesis by interfering with ribosome function. It is not a commonly used standard antibiotic, but is often used to select prokaryotic and eukaryotic cells transfected with neomycin resistance genes. It is widely used in gene transfer, gene knockout, resistance screening, and transgenic animals. |
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| Ulcho Biochemical Ltd | http://www.ulcho.com/ |
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