Lemairamin CAS#: 29946-61-0; ChemWhat Code: 1416908

IdentificationPhysical DataSpectra
Route of Synthesis (ROS)Safety and HazardsOther Data


Product NameLemairamin
Molecular StructureStructure of Lemairamin CAS 29946-61-0
CAS Registry Number 29946-61-0
MDL NumberMFCD00610628
Synonyms2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-;Lemairamin (WGX-50)
Molecular FormulaC19H21NO3
Molecular Weight311.37

Physical Data

AppearanceWhite powder
Melting Point, °C Solvent (Melting Point)
124 – 126
124.5 – 126acetone
119 – 120toluene
122 – 124acetone, hexane
127aq. ethanol


Description (NMR Spectroscopy)Nucleus (NMR Spectroscopy)Solvents (NMR Spectroscopy)Temperature (NMR Spectroscopy), °C Frequency (NMR Spectroscopy), MHz
Chemical shifts1Hchloroform-d1500
Chemical shifts13Cchloroform-d1125
Chemical shifts1Hdimethylsulfoxide-d6300
Chemical shifts, Spectrum1Hchloroform-d1300
Chemical shifts, Spectrum13Cchloroform-d124.84125
Description (IR Spectroscopy)Solvent (IR Spectroscopy)
Bandsneat (no solvent, solid phase)
Description (UV/VIS Spectroscopy)Solvent (UV/VIS Spectroscopy)Comment (UV/VIS Spectroscopy)Absorption Maxima (UV/VIS), nmExt./Abs. Coefficient, l·mol-1cm-1
Absorption maximamethanol206, 277

Route of Synthesis (ROS)

Route of Synthesis (ROS) of Lemairamin CAS 29946-61-0

Route of Synthesis (ROS) of Lemairamin CAS 29946-61-0

With sodium hydroxide In dichloromethane at 20℃; for 3h; Schotten-Baumann Reaction;91%
With sodium hydroxide In dichloromethane; water at 20℃; for 3h; Schotten-Baumann Reaction;91%
Experimental Procedure
An amount of 458mg of cinnamoyl chloride (2.76mmol) dissolved in CH2Cl2 (1mL) was added dropwise at 0°C to a solution of 2-(3,4-dimethoxyphenyl)ethylamine (500mg, 2.76mmol) in CH2Cl2 (20mL) and 5% aqueous NaOH (4.4mL) with stirring at room temperature for 3h. Then, the mixture was stirred with 2.5% aqueous HCl. The organic solution was washed with brine (2×10ml) and H2O (2×10ml), dried over anhydrous Na2SO4 and evaporated to dryness. The residue obtained was purified by silica gel column chromatography (Hexane/CH2Cl2/EtOAc, 20:70:10) to afford the acetamide 1 (781mg, 91%) as a white oil. 1H NMR (500MHz, CDCl3): δ=7.62 (d, J=15.6Hz, 1H, CH-β).

Safety and Hazards

No data available

Other Data

TransportationUnder room temperature and away from light
HS Code
StorageUnder the room temperature and away from light
Shelf Life2 years
Market Price
Toxicity/Safety Pharmacology
Quantitative Results
Use Pattern
Lemairamin CAS#: 29946-61-0 used as the next generation of anti-aging material. And Lemairamin has some applications in the medical field, primarily due to its effects on the nervous system.

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