IpgD, phosphatidylinositol-4,5-bisphosphate 4-phosphatase I, phosphatidylinositol-4,5-bisphosphate 4-phosphatase II, phosphoinositide phosphatase, PtdIns(4,5)P2 4-phosphatase, PtdIns-4,5-P2 4-phosphatase type I, PtdIns-4,5-P2 4-phosphatase type II, SigD, type I 4-phosphatase, type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase, type I PtdIns-4,5-P2 4-Ptase, type II 4-phosphatase, type II PtdIns-4,5-P2 4-Ptase
EC Number
3.1.3.78
CAS Registry Number
Comments
Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC?3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2?as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P?or PtdIns3P?[2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P?and thereby control p53-dependent apoptosis [3].
