Anti-C-Reactive Protein (CRP) Antibody

AntigenDescriptionProperties
Safety InformationImagesOther Info

Antigen

NameC-Reactive Protein (CRP)
SynonymsCRP; PTX1; C-reactive protein; pentraxin-related; pentraxin 1

Description

NameAnti-C-Reactive Protein (CRP) Antibody
SynonymsC-Reactive Protein; C-reactive protein, pentraxin-related; CRP; MGC88244; pentraxin 1
HostMouse; Goat; Rabbit
ReactivityAll species
Antibody Product Type  Primary
UseDetection; Capture
Conjugate Unconjugated; Biotin; APC; Alkaline Phosphatase (AP); FITC; HRP; PE
SpecifityThe antibody is raised against CRP. It has been selected for its ability to recognize CRP.
ApplicationELISA; Immunohistochemistry (IHC); Western Blotting (WB); Immunofluorescence (fixed cells) (IF/ICC); Immunoprecipitation (IP); Cell-ELISA (cELISA); Immunoassay (IA); Immunocytochemistry (ICC)

Properties

FormLiquid/Lyophilized
HandlingThe antibody solution should be gently mixed before use.
Storage ConditionStore at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for a year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
ClonalityMonoclonal/Polyclonal
IsotypeIgG

Safety Information

RIDADRNONH for all modes of transport
Flash Point(F) Not applicable
Flash Point(C) Not applicable

Images

Anti-C-Reactive Protein (CRP) Antibody in WBAnti-C-Reactive Protein (CRP) Antibody WB
Anti-C-Reactive Protein (CRP) Antibody in IHCAnti-C-Reactive Protein (CRP) Antibody IHC
Anti-C-Reactive Protein (CRP) Antibody in flowAnti-C-Reactive Protein (CRP) Antibody in flow

Other Info

About the antigenCRP is a plasma protein involved in host defense by promoting agglutination, bacterial capsular swellling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. It also scavenges nuclear material released from damaged circulating cells. The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. CRP has two isoforms produced by alternative splicing. CRP is synthesized by the liver in response to factors released by fat cells. It is a member of the pentraxin family of proteins. The levels of CRP rise in response to inflammation. Human C-reactive protein (CRP) is the classical acute phase reactant, the circulating concentration of which rises rapidly and extensively in a cytokine-mediated response to tissue injury, infection and inflammation. Serum CRP values are routinely measured, empirically, to detect and monitor many human diseases. However, CRP is likely to have important host defence, scavenging and metabolic functions through its capacity for calcium-dependent binding to exogenous and autologous molecules containing phosphocholine (PC) and then activating the classical complement pathway. CRP may also have pathogenic effects and the recent discovery of a prognostic association between increased CRP production and coronary atherothrombotic events is of particular interest.

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