Anti-CKMB (CK-MB, one isoenzyme of CK, creatine kinase CAS#: 9001-15-4, EC 2.7.3.2) antibody

AntigenDescriptionProperties
Safety InformationImagesOther Info

Antigen

NameCK-MB
SynonymsCK MB; CPK MB; creatine kinase MB; 9001-15-4; 2.7.3.2

Description

NameAnti-CKMB antibody
SynonymsKMB antibody, Anti-CKMB antibody, Creatine Kinase-MB Isoenzyme antibody, CK-MB antibody
HostMouse; Goat; Rabbit
ReactivityAll species
Antibody Product Type  Primary
UseDetection; Capture
Conjugate Unconjugated; Biotin; APC; Alkaline Phosphatase (AP); FITC; HRP; PE
SpecifityRecognizes CK-MB, one isoenzyme of CK, creatine kinase.
ApplicationELISA; Immunohistochemistry (IHC); Western Blotting (WB); Immunofluorescence (fixed cells) (IF/ICC); Immunoprecipitation (IP); Cell-ELISA (cELISA); Immunoassay (IA); Immunocytochemistry (ICC)

Properties

FormLiquid/Lyophilized
HandlingThe antibody solution should be gently mixed before use.
Storage ConditionStore at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for a year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
ClonalityMonoclonal/Polyclonal
IsotypeIgG

Safety Information

RIDADRNONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable

Images

Anti-CKMB antibody in ELISAAnti-CKMB antibody in ELISA

Other Info

About the antigenCreatine kinase (CK) is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of creatine and consumes adenosine triphosphate (ATP) to create phosphocreatine and adenosine diphosphate (ADP). This CK enzyme reaction is reversible, such that also ATP can be generated from PCr and ADP. In the cells, the “cytosolic” CK enzymes consist of two subunits, which can be either B (brain type) or M (muscle type). There are, therefore, three different isoenzymes: CK-MM, CK-BB and CK-MB.
Clinical DiagnosisPatients with skeletal muscle disease, acute muscle exertion, chronic renal failure, and cocaine use can have elevations in levels of CK-MB in the absence of infarction. In order to distinguish true positive elevations (secondary to myocardial injury) from the false positive elevations (due to skeletal muscle injury), the measurement of CK-MB as a percentage of total CK has been used to calculate relative index. A CK-MB to CK ratio of > 6% is reported to be specific for myocardial injury, whereas a ratio of < 6% is consistent with skeletal muscle damage or non-cardiac causes.

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