Anti-cTnI (Troponin I CAS#: 7108-40-8) Antibody

AntigenDescriptionProperties
Safety InformationImagesOther Info

Antigen

NameTroponin I
SynonymsTroponin I; Human Heart; hcTnI; 7108-40-8

Description

NameAnti-cTnI Antibody
SynonymsTroponin I cardiac (cTnI), antibody; Anti-Troponin I antibody; Cardiac Troponin I antibody; Cardiac Troponin antibody; Cardiac Troponin I antibody; Anti Troponin I antibody; Cardiac Troponin antibody; Troponin I antibody
HostMouse; Goat; Rabbit
ReactivityAll species
Antibody Product Type  Primary
Conjugate Unconjugated; Biotin; APC; Alkaline Phosphatase (AP); FITC; HRP; PE
SpecifityThree antibodies are available. Antibody 1 recognizes CtnI-TnC. Antiboday 2 recognizes CtnI-TnT-TnC and Antibody 3 only recognizes CtnI, which does not cross-react with the other two.
ApplicationELISA; Immunohistochemistry (IHC); Western Blotting (WB); Immunofluorescence (fixed cells) (IF/ICC); Immunoprecipitation (IP); Cell-ELISA (cELISA); Immunoassay (IA); Immunocytochemistry (ICC)

Properties

FormLiquid/Lyophilized
HandlingThe antibody solution should be gently mixed before use.
Storage ConditionStore at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for a year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
ClonalityMonoclonal/Polyclonal
IsotypeIgG

Safety Information

RIDADRNONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable

Images

Anti-cTnI Antibody in ELISAAnti-cTnI Antibody in ELISA
Anti-cTnI Antibody in WBAnti-cTnI Antibody in WB

Other Info

About the antigenHuman troponin I is presented in cardiac muscle tissue by a single isoform with molecular weight 23876 Da and it consists of 209 amino acid residues. cTnI molecule contains two serines in the 22 and 23 positions. Both amino acid residues can be phosphorylated in vivo by protein kinase A, so four forms of protein – one dephospho, two monophospho and one bisphospho – can coexist in the cell. Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Cardiac Troponin T is important in proper muscle function and myofibril formation. In the human heart, four cTnT isoforms are expressed in a developmentally regulated manner. Cardiac Troponin T expression in the human heart is affected by heart failure. Mutations within the Cardiac Troponin T protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the Cardiac Troponin T gene undergo alternative splicing that results in many tissue-specific isoforms.

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